The Seventh Annual International Symposium on

Man & His Environment in Health and Disease

February 23-26, 1989

Sheraton Park Central Hotel - Dallas, Texas


Faculty:

Nicholas Ashford, Ph.D., J.D.
Associate Professor of Technology & Policy
M.I.T.
77 Mass. Avenue, Building E40-239
Cambridge, MA 02139 (617) 253-1664

Iris R. Bell, M.D.
Instructor in Psychiatry
Harvard Medical School
McLean Hospital
115 Mill Street
Belmont, MA 02178 (617) 855-3183

Jacques Benveniste, M.D.
Director of Research
Institute National de la Sante
et de la Recherche Medicale
INSERM U 200
University of Paris-Sud
32 rue des Carnets
Clamart, 92140 France (011-33-1-46321207)

Abrahm Ber, M.D.

20635 N. Cave Creek Blvd.

Phoenix, AZ 85024 (602) 279-3795
 

Jeffrey S. Bland, Ph.D.

President

HealthComm, Inc.

3215-56th Street N.W., Suite 1-B

Gig Harbor, WA 98335 (206) 851-3943
 

Joel R. Butler, Ph.D., Professor

Psychology Department

North Texas State University

Denton, TX 76201 (817) 565-2643
 

Mark R. Cullen, M.D.

Director

Yale New Haven Occupational Medicine Program

Yale University School of Medicine

333 Cedar Street

New Haven, CT 06510 (203) 785-5885
 

Dr. Jose Delgado

Professor of Neurobiology

Center for Neurobiological Studies

L.B.E., Velazquez 31

28001 Madrid, Spain 275-0667
 

Nancy A. Didriksen, Ph.D.

Environmental Health Psychologists

1401 Airport Freeway

Bedford, Texas 76021 (817) 540-4414
 

Ervin J. Fenyves, Ph.D.

Professor of Physics

University of Texas at Dallas

P. O. Box 830688

Richardson, TX 75083-0688 (214) 690-2971
 

Ronald Finn, M.D.

Consultant Physician

Royal Liverpool Hospital

Prescot Street

Liverpool L7 8XP

Merseyside, England (011-44-51-709-0141 X2465)
 

H. P. Friedrichsen, M.D.

Medical Director of the First German

Hospital for Environmental Medicine

Veramed Clinic

Schulstr. 4

8221 Inzell, W. Germany (011-49-866567150)
 

Zane Gard, M.D.

3888 B Calle Fontonada

San Diego, CA 92123 (619) 571-0300
 

Arthur S. Hume, Ph.D.

Assistant Professor

Department of Pharmacology-toxicology

University of Mississippi Medical Center

2500 N. State Street

Jackson, MS 39216-4505 (601) 984-1612
 

Satoshi Ishikawa, M.D.

Professor and Chairman

Department of Ophthalmology

Kitasato University

1-51-1 Kitasato

Sagamihara, Kanagawa 228, Japan (011-81-427-78-8464)
 

Alfred R. Johnson, D.O.

Environmental Health Center - Dallas

8345 Walnut Hill Lane, Suite 205

Dallas, Texas 75231-4262 (214) 368-4132
 

Amanullah Khan, M.D.

9000 Harry Hines

Dallas, Texas 75235 (214) 351-8270
 

John L. Laseter, Ph.D.

Enviro-Health Systems, Inc.

990 No. Bowser Road, #800

Richardson, Texas 75081 (214) 234-5577
 

Andrew Marino, Ph.D.

Associate Professor

Department of Orthopaedic Surgery

LSU School of Medicine in Shreveport

P. O. Box 33932

Shreveport, LA 71130-3932 (318) 674-6180
 

Lewis W. Mayron, Ph.D.

Environmental Medicine and Ecologic Science, Inc.

1779 Summer Cloud Drive

Thousand Oaks, CA 91362 (805) 492-2458
 

Jean Monro, M.D.

Breakspear Hospital

Abbots Langley

Hertfordshire, WD5 OPU

England (011-44-92776133)
 

Jon B. Pangborn, Ph.D.

30 W. 101 Roosevelt Road

W. Chicago, IL 60185 (312) 231-3649
 

Doris J. Rapp, M.D.

1421 Colvin Blvd.

Buffalo, NY 14223 (716) 875-5578
 

William J. Rea, M.D.

Director

Environmental Health Center - Dallas

8345 Walnut Hill Lane, Suite 205

Dallas, Texas 75231-4262 (214) 368-4132

Sherry A. Rogers, M.D.

Medical Director

Northeast Center for Environmental Medicine

2800 West Genesee Street

Syracuse, NY 13219 (315) 488-2856
 

Gerald H. Ross, M.D.

Environmental Health Center - Dallas

8345 Walnut Hill Lane, Suite 205

Dallas, Texas 75231-4262 (214) 368-4132
 

Colin G. Rousseaux, B.V.Sc., Ph.D.

Associate Professor

Dept. of Veterinary Pathology

Western College of Veterinary Medicine

University of Saskatchewan

Saskatoon, Saskatchewan

S7N OWO Canada (306) 966-7294
 

F. Fuller Royal, M.D.

6105 W. Tropicana Ave.

Las Vegas, NV 89103 (702) 732-1400
 

Douglas M. Sandberg

Professor of Pediatrics

Director, Div. of Gastroenterology and Nutrition

University of Miami

Children's Hospital Center

1500 N.W. 12th Ave. #1027-28

Miami, FL 33136 (305) 547-6511
 

David W. Schnare, MSPH, Ph.D.

8311 Crestridge road

Fairfax Station, VA 22039 (202) 382-5541
 

Cyril W. Smith, Ph.D.

Department of Electronic & Electrical Engineering

University of Salford

Salford M5 4WT

England (011-44-61-736-5843)
 

Johannes C. Steenkamp, H.D., D.O.

Department of Public Health & Prev. Medicine

Texas College of Osteopathic Medicine

Camp Bowie at Montgomery

Ft. Worth, TX 76107 (817) 735-2252

Ellen Widess

Director of Environmental Health and Safety

Texas Department of Agriculture

P. O. Box 12847

Austin, Texas 78711 (512) 463-7534
 

Said Youdim, Ph.D.

8345 Walnut Hill Lane, Suite 205

Dallas, Texas 75231 (214) 368-4132
 
 
 

Faculty Abstracts:
 

Nicholas A. Ashford, Ph.D., J.D., Massachusetts Institute of Technology, Cambridge, Massachusetts

LEGAL AND REGULATORY CHALLENGES FOR LOW LEVEL EXPOSURES
 

As advances in both analytical measurement technology and in clinical observations of health effects due to low level exposures to toxic substances have occurred, new demands for response from the public health and regulatory agencies have arisen. Attribution over both the sources of exposure and of causation are especially confounded. Yet, governmental entities are being asked to respond. New challenges and opportunities for both environmental and occupational health professionals will be discussed.
 
 
 

Iris R. Bell, M.D., Ph.D., Harvard Medical School, McLean Hospital, Belmont Massachusetts

NUTRITIONAL FACTORS IN GERIATRIC DEPRESSION
 

This paper reviews relevant clinical literature and the author's recent research findings on B complex vitamins, zinc and other laboratory measures of nutritional status in geriatric psychiatry inpatients with major depression. Although some investigators have found over 50% of new admissions with B vitamin deficiencies in general inpatient psychiatric populations, this writer observed much lower frequencies of B1, B2, B6, folate, and B12 blood level deficiencies in our sample of geropsychiatric inpatients. However, serum zinc levels are abnormally low in the majority of such patients. Lack of family psychiatric history and later age at onset may be associated with poorer vitamin status in these individuals. Other pilot work suggests that low-dose supplementation of vitamins B1, B2, and B6 may improve cognitive dysfunction but not depression better than placebo during concomitant antidepressant medication treatment. Available data suggest several important hypotheses to guide future studies: (1) central nervous system levels and function of the B vitamins may be deficient despite normal blood vitamin levels and/or peripheral enzyme function tests; (2) in the treatment of severe depression, vitamins may best serve as an adjunctive rather than primary modality in combination with standard antidepressants; (3) research must focus on biochemically interrelated nutrients at the same time rather than isolate individual B vitamins or minerals for study; (4) as in studies of environmental toxins, prescreening for individuals vulnerable to nutritional insult may be the best research strategy in evaluating response to nutrient supplementation.
 

PSYCHOPHARMACOLOGY IN ENVIRONMENTAL ILLNESS
 

This paper summarizes the author's clinical data on environmental illness patients who sought psychiatric treatment (EIP). As others have noted, EIP presented polysymptomatic syndromes with prominent complaints of chronic fatigue, depression, anxiety, irritability, headaches, gastrointestinal distress, and other somatic disturbances. EIP in the author's practice also reported extremely high frequencies of positive family histories for psychiatric disorders (63%), alcohol and/or drug abuse (54%), asthma/local allergies (51%). Within psychiatry, the clinical presentation and course of severely-ill EIP most closely resembled those of Briquet's Syndrome ad defined by Guze's group1, with superimposed atypical depression and anxiety disorders. In many cases, these EIP individuals were labile in terms of affective, cognitive, and psycho physiological manifestations; they often showed only portions of DSM-111R diagnosable psychiatric syndromes. Furthermore, a subset of the EIP responded in limited degree to standard psychiatric medications, including lithium, alprazolam, clonazepam, tricyclic and monomine oxidate inhibitor antidepressants. Notably, the frequency of reported upper respiratory infections in certain susceptible patients decreased during treatment with lithium and certain antidepressants. This conceptualization of a subset of EIP facilitates the synthesis of available data on the neurochemical, genetic, psychopharmacological, and psychological aspects of Briquet's, atypical and major depression, and panic disorder with clinical characteristics of EIP to suggest promising areas for further research on EIP.

__________________________________________________

1 Perley MJ, Guze, SB. NEJM 266:421-26, 1962
 
 
 

J. Benveniste, M.D., INSERM, U.200, Clamart, France

BIOLOGICAL EFFECTS IN THE ABSENCE OF LIGAND IN USUAL MOLECULAR FORM: ELECTROMAGNETIC ORDERING OF WATER? IN VIVO AND IN VITRO EFFECT OF HOMEOPATHIC REMEDIES
 

Even at extreme dilutions, some substances are able to influence cell response. In a first study, mice received between 1 x 10-19 of silica, a substance cytotoxic for macrophages, for 25 days. The synthesis of the inflammatory either-lipid paf-acether by peritoneal macrophages was increased by 30 to 65% in treated mice as compared to untreated ones. The observed differences were highly significant in all experiments, demonstrating an unexplained in vivo cellular effect of high dilutions of silica (Davenas et al., 1987, Eur. J. Pharmacol. 135:313). In two other studies, high dilutions substances specifically stimulated or inhibited human basophil. High and low dilutions of goat anti-human IgE antiserum induced a loss of basophil staining (achromasia). Successive peaks of basophil degranulation (40-60%) were observed with the anti-IgE antiserum ten-fold or hundred-fold diluted from 1 x 10-6 M down to concentrations (theoretical after the 14th ten-fold dilution) well below those generally used in classical pharmacology. The same process applied to a goat anti-human IgG antiserum gave no results (Davenas et al., 1988, Nature 33:816). High dilutions of two homeopathic drugs Lung Histamine and Apis Mellifica used for the treatment of allergic diseases significantly inhibited human basophil degranulation induced by 1 x 10-16 to 1 x 10-18 M anti-IgE antibody (Poitevin et al., 1988, Br. J. Clin. Pharmacol. 25:439). These data indicate that substances highly diluted - to the point that no molecule is present in the solution - do influence biological functions at the cellular or whole body level. It also suggested that the basophil degranulation test could be applied to the diagnosis at the cellular level of allergy-related diseases. An automatic basophil-counting machine is presently under development.
 
 
 

Abram Ber, M.D., Homeopathic physician, Phoenix, Arizona

THE DOMESTIC ANIMAL AS A SOURCE OF ILLNESS
 

Clinical ecologist and allergists are familiar with the potential of animal dander as an inciter of allergic symptoms. Domestic animals are also a potential source of infectious agents easily transferred to humans, especially children
 

The author describes a case involving a child brought to his care for a fever of unknown origin. Previous laboratory investigation and clinical consultation had failed to reveal a cause for the prolonged pyrexia..
 

The environmental history revealed that this child played with numerous pets which also included seven (7) cats. A stool specimen examined by an expert parasitologist working in the author's office revealed the presence of heavy infestation of Toxoplasma gondii.
 

Treatment consisted of the sublingual administration of the neutralizing dilution of toxoplasma antigen. The neutralizing dilution of toxoplasma antigen. The neutralizing dilution was found to be the 3rd dilution of a 1:5 and was found by measurement of skin resistance utilizing a Dermatron (electro acupuncture device). The child improved immediately and made a complete recovery in several weeks.
 

Jeffrey S. Bland, Ph.D., HealthComm, Inc., Gig Harbor, Washington

PHYTOPHARMACEUTICALS AND THE RELATIONSHIP TO ECOLOGICAL MEDICINE
 

The past five years has witnessed a remarkable resurgence of interest in phytopharmaceutical-based preparations. The basic science that underlies many of these preparations is now becoming better understood although the legacy for their effectiveness can be traced back to lower an anecdote of several thousand years.
 

New phytopharmaceutical substances which have interest in environmental medicine include Ginkgo biloba, Echinacea augustifolia, feverfew, silymarin and Aloe vera. This presentation will focus on the phytopharmacy of these particular herbal preparations in the context of environmental medicine. Questions concerning the ethnobotany, pharmacognosy and standardized potency of these preparations will be discussed.
 

By utilizing these specific examples of herbal-based preparations, a more general review of the application of phytopharmacy in environmental medicine will be explored. Concerned relating to the concentration of active principles, dose response relationships of phytopharmaceuticals, the presence of zenobiotic contaminants and unit dose potency of herbal-based preparations will be discussed.
 

Closing this presentation will be a brief discussion concerning the loss of species diversity in the rain forest biome and the impact that has upon the botanical pharmacy and how this interrelates to questions concerning man and his environment.
 
 
 

Joel R. Butler, Ph. D, Professor of Psychology, University of North Texas, Denton, Texas

ECOLOGY OF THE MIND
 

In considering the totality of inner relationships of all organism, the universe of the mind and its ecological connection to health needs further examination. The mind/body interaction is woven together as much by imagery as by molecules. In far ranging activities from the first running of the under 4-minute mile to an increase in mother's milk or a psychological-classical conditioning of mast cells-the mind takes precedence over the molecule. The mind does not exist just from the skin in but is truly ecological in its recognition and response to those things cultural, spiritual, learned or psychological/physiological. It is a reservoir of attitudes, beliefs and hopes. Yet the mind is a great intangible to most even though it can heal or destroy. While the mind cannot substitute for bodily processes, it can certainly influence them-for better or worse. The reverse holds true as well but too often the approach to health is intentionally physiological and often only accidentally mental or psychological or a combination. The state of mind will generally reflect the state of total health and a mind/body ecological balance must be struck.
 
 
 
 
 

Mark R. Cullen, M.D., Yale University School of Medicine, New Haven Connecticut

MULTIPLE CHEMICAL SENSITIVITIES: TOWARD A COMMON UNDERSTANDING
 

The occupational medicine community, along with other community providers, has become increasingly exposed to patients with adverse reactions to multiple diverse chemical agents. Although many patients have been treated by clinical ecologists, broad debate rages in medical circles regarding the theories of pathogenesis, diagnostic and treatment methods for these. Until now this debate has been characterized by polemics on both sides, yielding more heat than light. In this talk I shall address strategies to progress beyond this state of affairs by utilizing the existing and considerable wisdom which each side has to offer.
 

Jose M. R. Delgado, M.D., Centro De Estudios Neurobiologicos, Madrid Spain

ELECTROMAGNETIC AND IDEOLOGICAL POLLUTION OF THE BRAIN

The modern proliferation of electrical plants, high power lines and electrically mechanized homes are sources of artificial magnetic fields which may influence biological activities. In our experiments we demonstrated the following effects induced by weak, very low frequency electromagnetic fields: (a) Modifications in the orientation of snails; (b) Polarographic changes of amino acids "in vitro"; (c) Influences on the synthesis of T-RNA; (d) Changes in learning and memory in mice; (e) Orientation and viability of drosophila; (f) Genetic changes in drosophila; (g) Bacterial growth; (h) Unitary activity of the stretch receptor in the crab; (I) Powerful modification in the development of chick embryos; (j) Effects on unitary activity of cerebellar Purkinje cells in the cat; (k) Changes in motor activity and sleep-wakefulness cycles in monkeys; and (l) Non-invasive modifications of the central nervous system using a special methodology. Utilization of electromagnetic energy represents risks and benefits for mankind requiring intelligent, ethical evaluation of results.
 

Attention should also be paid to a very subtle but powerful and widespread danger related to modern mass media communication technologies: the ideological pollution of the brain. Minds and bodies are directed with objectives imposed without the knowledge or consent of the individual. Mental and physiological functions are usurped by hidden forces without concern for personal identity.. Unfortunately a sensation of freedom may be provided when, in reality, there is a manipulation of ideologies, motivations and actions.
 

It is essential to be aware of the many dangers caused by different kinds of ecological, physiological and neurobiological pollution. Solutions must be found for the prevention and management of undesirable consequences.
 
 
 

Nancy A. Didriksen, Ph.D,, Environmental Health Psychologist, Bedford, Texas, and Joel R. Butler, Ph.D., University of North Texas, Denton, Texas

PATIENT COMPLIANCE: FACILITATION METHOD
 

Evidence is abundant for the incidents of noncompliance with various medical and/or psychological treatment regimens with attrition rates as high as 100% among patients including healthcare professionals. Major factors related to nonadherence include treatment variables (complexity and duration), patient variables (individual characteristics regarding social support, negativism, lack of resources), disease variables (stability of symptoms) and patient-healthcare provider interaction.
 

The behavior of healthcare providers as well as that of the patient can facilitate or interfere with treatment adherence. Factors such as effective communication, mutual goal setting, positive belief systems, empathy, concern, warmth, courtesy, explanatory style and efficacy of treatment itself should be considered for successful outcomes.
 

Ervin J. Fenyves, Ph.D., and Roy Kinslow, Ph.D., University of Texas at Dallas, Richardson, Texas

FURTHER STUDIES ON THE HAZARDS OF RADON EXPOSURE
 

Radon - 222 and its mother nucleus Radium - 226 pose an until now unidentified hazard: oil field waste, oil field pipelines and brine may have relatively high levels of radium contamination, and emanate high levels of radon gas. Structures, buildings and even children's playgrounds using materials, and equipment containing any of the above contaminated pipe-yards and other structural materials are posing a significant health hazard to the general population, and particularly to children.
 
 
 

Ronald Finn, M.D., F.R.C.P., Royal Liverpool Hospital, Liverpool, England

SENSITIVITY AS A CENTRAL CONCEPT IN ENVIRONMENTAL MEDICINE
 

Environmental Factors play an important role in many diseases. Environmental agents are common and disease rare, and it is likely that affected subjects are particularly sensitive to the relevant environmental agent. Clinical sensitivity is, therefore, important in the genesis of environmental disease.
 

Allergy is the classical example of sensitivity and is divided into immediate IgE reactions and delayed IgG and cellular reactions. Most food antibodies are IgG4 which are probably protective rather than pathogenic as the bind weakly to antigen and are poor activators of complement.
 

Most clinical sensitivities are probably biochemical and are based on defective enzyme systems. Thus, the slow acetylator genes predispose to isoniazid peripheral neuropathy and defects in oxidation and sulphate conjugation of dietary amines predispose to migraine. Addiction is largely determined by genetic factors in the presence of the addicting agent such as alcohol. It is also probably that the complications of tobacco are due to sensitivity rather than chance. Defects in the sodium pump predispose to hypertension and sensitivity to alcohol, tobacco and analgesics are of clinical relevance in individual patients.
 

Clinical sensitivities are of importance in Environmental Medicine and their management can be clinically rewarding. There are several types of sensitivity, many of them having a genetic basis.
 
 
 

Arthur S. Hume, University of Mississippi Medical Center, Jackson, Mississippi

BINDING OF TOXICANTS BY CARBONYL AND SULFIDE CONTAINING CHEMICALS
 

It may be of significance that endogenous carbonyl and sulfide containing chemicals are recognized to bind certain toxicant. It has long been recognized that sulfides will bind heavy metals and are used as antidotes for these chemicals. However, their binding activities at lower concentrations have not been significantly investigated. Since sulfide containing chemicals will bind significant amounts of heavy metals, sulfide containing amino acids could serve as scavengers for heavy metals, reducing their accessibility and enhancing their excretion. Carbonyl groups are relatively reactive groups and will react with a number of chemical functional groups. Carbonyl containing chemicals have been reported as binding several toxicants. Some examples are: alphketoglutaric acid binds cyanide; pyruvic acid binds sulfide; citric acid enhances the excretion of aluminum. It is reasonable that these agents could assist in binding and removing some toxicants especially those with long half-lives.

Satoshi Ishikawa, Yoshihiro Kojima, Iehiko Tsujisawa and Hirotsune Sako, Department of Ophthalmology, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.

OBJECTIVE DETERMINATION OF "FATIGUE" ON THE PERFORMANCE OF VISUAL DISPLAY TERMINAL (VDT) OPERATOR
 

Near triad of the eye is consisted of three responses, i.e., accommodation, pupil constriction and convergence. These responses were simultaneously recorded by using infrared optometer, pulillometer, and photoelectric oculographic devices. The stimulus to the eye was carried out with the velocity of 0.2 diopter (D) per sec. from -12 D to +12 D continuously, thus, quasi-static responses of the near triad were recorded. The subjects who complained of eye strain from ordinary hard work business (A) and the other subjects who also complained of the eye strain from VDT performance over 20 hours/week (B) were compared by measuring above parameters.
 

The results indicated that there were functional abnormalities of the near triad in both groups. Even with the minor abnormality of the responses, it was designated as "abnormal." The appearance rate of the abnormality of the near triad was 25.9% in Group A and 71.1% in Group B (p. 0.01). With the loading of the accommodative stimulus, the pupillary reaction was more involved in the VDT operator. A possible existence of parasympathicomimetic state was considered. A possible role to produce the eye strain in VDT performance will be presented.
 

RETINAL DEGENERATION POSSIBLY DUE TO ENVIRONMENTAL EXPOSURE TO ORGANOPHOSPHORUS PESTICIDES
 

Organophosphorus pesticides (OP) produces pathological changes in the ciliary muscle and in the optic nerve of both animals and humans. The effect of OP on the retina has been functionally studied using the electro-retinogram in the acute and subacute stages as the reduction of a and b waves of the scotopic ERG. Decrease in the amplitude of visually evoked responses (VER) as well as potentials recorded at superficial layer of the superior colliculus has been introduced. Functional and histological changes in the retina induced by chronic administration of OP have not been studied except Imai's work (1).
 

In this presentation, we would report a case of chronic OP intoxication who died by myocardial infarction. He was a professional OP sprayer for about 20 years spraying mainly parathion, fenitrothion, fenthion DDVP, etc. He has no consanguinity but presented severe choroidal sclerosis with retinal pigmentary degeneration. This unique histopathological finding will be reported.
 

1. Imai, H et al: Retinal degeneration in rats exposed to an Fenthion. Environmental Research 30:453-465, 1983.
 
 
 

Alfred R. Johnson, D.O., William J. Rea, M.D., Environmental Health Center - Dallas, Texas and Satoshi Ishikawa, M.D., and Shinji Shirakawa, M.D., Department of Ophthalmology, School of Medicine, Kitasato University, Kanagawa, Japan.

ENVIRONMENTAL PATIENT PROFILE, 200 SUBJECTS
 

Diagnosing and evaluating the environmentally sensitive patient is the ultimate challenge for the practicing physician. Two hundred first-time admit patients to the Environmental Care Unit were evaluated for multiple demographic, laboratory and psychological perimeters. Most frequent complaints involved that of central nervous system with headache, fatigue, and poor concentration. Fifty-two percent were of the third and fourth decade of life. At least 60% had attended college. Laboratory work revealed frequent immune dysregulation with 14% revealing positive antinuclear antibodies. Many similarities exist with the current CDC criteria for diagnosing Chronic Fatigue Syndrome. Careful and complete environmental illness evaluation and treatment program is necessary.
 
 
 

Alfred R. Johnson, D.O., William J. Rea, M.D., Environmental Health Center - Dallas, Texas

ADDITIONAL OBSERVATIONS OF EYE RESPONSE WITH CHEMICAL SENSITIVITIES
 

Autonomic nervous system complaints are frequently present among the environmental sensitivity patients. Quantitative evaluation of the autonomic nervous system has been difficult prior to the development of the bionuclear IrisCorder. Analysis of the iris reaction to light stimuli by a high precision infrared video camera measures the real time variation in pupil area of both eyes in response to a light stimulus. Chemically sensitive individuals, as well as those that have been exposed specifically to pesticides, show a deviation from normal controls, producing a sympatholytic or cholinergic nerve response pattern.
 
 
 

Lewis W. Mayron, Ph.D., Environmental Medicine and Ecologic Science, Inc. Thousand Oaks, California 91362

NEUTRALIZATION OF THE BRITTLE PATIENT
 

A system of neutralization fine-tuning was introduced in 1981 which defined fractions of fifths and twenty-fifths of a whole number interval. Ultrafine tuning was performed by using increments of 0.01 ml between the twenty-fifths. This system has yielded data that appears to define three types of lesions: 1) Sensitivity to an antigen; 2) Intolerance or brittleness to an antigen; 3) Instability to an antigen. In highly intolerant or brittle states, ultrafine tuning has proven to be inadequate, thus necessitating the development of a system we have termed averaging. Averaging enables the physician to tune a titration of five-trillionths of an interval, if needed. Thus, not only does the body respond to specific serial five-fold dilutions of an antigen but it also responds clearly and dramatically to minutes changes in concentration, especially in the brittle patient. This has been particularly helpful in the asthmatic patient, the migrainer, the seizure patient, and the patient with chronic infections.
 
 
 

Jean Monro, M.D., Breakspear Hospital for Allergy and Environmental Medicine, Hertfordshire, England

BRAIN FREQUENCY ANALYSIS
 

We have shown that patients will react to very low field strength frequencies through the whole frequency spectrum from less than 1 Hz to 4 gigaHz. The patients evince symptoms which can be negated. The "neutralizing" frequency can be administered in the form of similarly charged vaccines. There is no objective evidence of the "neutralizing" endpoint other than the clinical signs which can be observed. The most electrical tissue in the brain can be assessed by E.E.G. Computerized E.E.G. tracings have been monitored simultaneously with exposure to weak electromagnetic frequencies through the similar range, viz. 1 Hz. - 200 Hz. That frequency has been selected for the provision of a frequency generator. The patient can be provided with weak field strength frequencies through the miniature computer. The device can be worn close to the body, as in a watch or pendant. It has been shown to reduce the frequency, severity and duration of migraine in 98% of a group of patients. Data concerning the pilot study will be presented and the principles demonstrated.
 
 
 
 
 

Jon B. Pangborn, Ph.D., President, Bionostics, Inc., Vice President, Doctor's Data, Inc., Consultant, Klaire Laboratories, W. Chicago, Illinois

LABORATORY ASSESSMENTS OF CHEMICAL TOXICITY AND ENZYMATIC DETOXICATION
 

One process by which the human body cleanses itself is by enzymatic detoxication which occurs mainly in liver tissue. Alcohol, some medications, street drugs (narcotics) normally induce or increase the activities of certain hepatic microsomal enzymes. One reliable marker for increased activity of such enzymes is the level of D-glutaric acid in a 24-hour urine sample. Many Zenobiotic that are pesticides, herbicides or fungicides undergo epoxidation followed by conjugation to form mercapturic acids. A laboratory test procedure is being developed at Doctors' Data Laboratory to monitor conjugated mercapturic acids in urine. Other laboratory tests that are useful in assessing an individuals's capacity for enzymatic detoxication include determination of functional vitamin activities, measurement of amino acid adequacies, especially those of cystine and taurine, and measurement of the adequacy of certain minerals, especially selenium, manganese, zinc and copper.
 
 
 

D. J. Rapp, M.D. and D. Cantor, Ph.D., Buffalo, New York

MULTIPLE PARAMETER STUDIES IN ENVIRONMENTALLY ILL CHILDREN
 

10 patients, aged 6 to 16 years, and one adult with diverse cerebral allergic symptoms were part of a pilot study to evaluate neurometric changes during provocation testing. The patients were tested with a variety of common allergens. Constant brainwave and video recordings were conducted during the baseline, after placebos, at the peak of the reaction and after neutralization. Bender Gestalt tests, and the ability to write were similarly monitored along with changes in C3, C4, histamine, serotonin, Elisa tests and 43 amino acids. The confounding variables will be discussed.
 

The results of the above will be presented as well as details about two patients, in particular. One showed cerebral changes which correlated with the pulse and observations noted during provocation neutralization testing for wheat. The other appeared to have a brain stem reaction during a rice test. The neurometric recording of the cerebrum showed insignificant changes. Video excerpts will be presented. This pilot study should provide insight and direction so that a well-designed larger study will be possible in the future.
 

Unfortunately, analysis of the resting and concentration phases of the neurometric study could not be completed on all the patients prior to this presentation.
 
 
 

William J. Rea, M.D., Yaqin Pan, M.D., Peking China, Salvador Figueroa, M.D., Tampico, Mexico, and Rintu Khan, M.D., Dhaka, Bangladesh

ELECTROMAGNETIC FIELDS, PART II
 

Blind studies were performed under environmentally controlled conditions in electricity and electromagnetically measured porcelain steel rooms. Studies using a B-K (3030 sweep) Precision Dynasean frequency generator were performed on 76 patients who reported thy were electrically sensitive and 24 controls. Ages ranged from 5-75 with a mean of 40.4 with 18 males and 58 females. Patients were tested with 2-5 minutes exposure per frequency with blanks being the machine off for 5 minutes. There were at least 10 separate challenges in 5 blanks per patient. Reaction occurred in 56 of 76 patients in the range of .1 Hz to 5 Hz. More than one frequency produced reactions in each patient that reacted. 56 (73%) patients reacted to challenge and 27 (35%) to placebo (includes 14 patients who reacted to previous challenge). The greatest number of patients reacted at 1 Hz (34), 10 Hz (44) 100 Hz (40) l KHz (42), 10 KHz (34), 100 Khz (31), 1MHz (33) and 5 MHz (30). The main signs and symptoms reproduced were neurological, cardiovascular, respiratory, musculo-skeletal, gastrointestinal, ocular and skin.
 

It is clear from this study that a group of patients exist who are sensitive to a broad range of frequencies and effect can be elicited under environmentally controlled conditions.
 
 
 

William J. Rea, M.D., Environmental Health Center - Dallas, Texas and Michael Rath, Senior Medical Student, Munich, Germany

SERIES OF PATIENTS WITH ELECTROMAGNETIC SENSITIVITIES (MEASUREMENT) - PART I
 

Measurements of electric and magnetic fields of different areas outside homes, apartments and office buildings were performed using the E.M.F. and electric detector by Genitron. Less polluted rural ranch area of Texas showed 0 . V/M + 0 nT. These areas were at least 100 feet from any power source. Both areas were at least 60 miles from the Dallas metropolitan area. In addition, environmentally controlled porcelain trailers that were connected to 110 volt power lines by an extension cord were used for indoor air measurements. Ten units each read 0 V/M + 0 nT.
 

The less polluted areas and units may be used for references of what the ideal or control areas should be. In addition, measurements of electric and magnetic fields were measured from high tension power lines in the U.S., Japan, England and Germany. Electric fields were negligible at any distance. However, magnetic fields were first detected at a distance of one mile in 20/20 lines measured in England; ½ mile in Germany 6/6; 300-500 feet in the U.S. 20/20 and Japan 10/10. Once the magnetic field was detected, it increased linearally until it was off scale (over 1000 n/T) at or near being underneath the power line. Apartments and houses showed electric fields +25 to 100 n/T in the U.S., England, Japan and Germany. Shopping centers in Texas and Ohio were off the scale (1000 n/T) up to 300 feet from the buildings. Airports in Munich, London, Tokyo, Las Vegas, Dallas, Toledo, and Detroit were off the scale as well 1000 n/T.
 
 
 

William J. Rea, M.D., Environmental Health Center - Dallas, Texas and Shingi Shirakawa, M.D., Kanagawa, Japan, Yaqin Pan, M.D., Peking China, Daniel Martinez, M.D., Dallas, Texas

EVALUATION OF AUTONOMIC NERVOUS SYSTEM DYSFUNCTION VIA THE IRISCORDER AND OTHER OBJECTIVE PARAMETERS AFTER CHEMICAL DEPOLLUTION
 

Pupillography using the Iriscorder (Ishikawa and Hamamtsu) can measure autonomic nervous system dysfunction. One can objectively measure changes in the autonomic nervous system including sympathetic, cholinmergic, sympatholytic and cholinergolytic functions. Chemically sensitive patients were measured before, during and after treatment showing objective changes during this process. 20 consecutive chemically sensitive patients (16 females and 4 males) with a mean age of 43 years were followed pre, during and after sauna. 9 (45%) improved, 4 (20%) got worse and 7 (35%) remained the same. These were correlated with blood levels of toxic chemicals. In addition, changes can be shown before and after inhaled challenge and before and after intradermal challenge as well as intradermal neutralization.
 

Balance studies using the computerized posterography balance unit by Neurocom has been very useful in analyzing patients with central and periferal nervous systems sensitivity, as well as inner ear involved by toxic chemicals. This test for total equilibrium is a computerized moving platform and moving visual surroundings. This system assesses motor and sensory deficiencies affecting posture and equilibrium. It creates, in a clinical setting, the types of situations which cause a dysfunction of equilibrium in patients in their daily lives. By using these parameters we can find that one has more objective parameters in which to evaluate the chemically sensitive individual.
 
 
 

Sherry A. Rogers, M.D., Northeast Center for Environmental Medicine, 2800 W. Genesse Street, Syracuse, New York 13219

A NEW APPROACH TO ENVIRONMENTAL ILLNESS TREATMENT FAILURES
 

Environmental Illness (E.I.) is clearly a product of a maladapted detoxication system. We are the first generation exposed to an unprecedented number of chemicals and simultaneously eating a more nutrient depleted diet. Since macrobiotics (MB) has cleared cancers, it should be able to clear E.I., but requires modifications to be tolerated. Eighteen of twenty treatment failures of the total load program had no options remaining, and many were even intolerant of non-phenol, non-glycerine injections and any supplements. They were markedly improved on MB, tolerating foods, mold and chemicals for the first time in years. They also corrected resistant nutrient deficiencies, had more energy and a state of optimistic well being, and the improvement progressed the longer they were on the program. Many no longer needed injections. Two out of twenty decided they were unable to do the program. MB has since provided an inexpensive option for over 50 patients who had no options left, and is compatible with ecologic principles.
 
 
 

Gerald H. Ross, M.D., C.C.F.P., International Fellow in Environmental Medicine, Environmental Health Center - Dallas, Texas

A COMPARISON STUDY OF ENVIRONMENTALLY SENSITIVE PATIENTS AND CONTROLS, MEASURING TOXICOLOGICAL, NUTRITIONAL, IMMUNOLOGICAL AND BIOCHEMICAL PARAMETERS.
 

A multi parameter study was conducted at the Environmental Health Center - Dallas in which hematology, immunology, trace mineral analysis, organic hydrocarbons and depollution enzymes were assessed in a series of chemically sensitive patients and compared to a group of volunteer controls. The controls did not use tobacco, alcohol, tea, coffee, medications or nutritional supplements, and had no ongoing health problems.
 

Statistically significant differences were found in the nutrient status, biochemistry, toxic pollutant load and other parameters between these groups, which will be discussed.
 

These findings have important implications, concerning the degree to which both patients and healthy people are affected by environmental pollutants, and the factors which are associated with pollutant load.
 

*This study was conducted with the cooperation of the Church of Jesus Christ of Latter-Day Saints, Dallas East Stake and supported by Accuchem Laboratory of Richardson, Texas, Doctor's Data of Chicago, Monroe Medical Labs of New York and North Texas Immunology Lab of Dallas.
 
 
 

C. G. Rousseaux, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

NUTRITIONAL ASPECTS OF TRACE ELEMENT INTERACTIONS
 

Trace elements are true hormetic agents in that disease occurs in both deficient and excess states. Unfortunately, unraveling the issue of trace element nutrition is fraught with difficulty as each element cannot be considered in isolation. In fact, competition of one trace element with another may cause a deficiency state in an individual who has "normal" levels of the "deficient" trace element. This phenomenon means interpretation of trace element results can only be undertaken in conjunction with results of known competing elements eg. copper and molybdenum. Many interactions are known, hence examination of interactions will be limited to: copper-sulphur-molybdenum, zinc-vitamin A, zinc-calcium, zinc-copper, zinc-lead, nickel-copper-iron, and manganese-iron-zinc. The complexity of these elemental interactions means nutritional studies involving trace elements must be made with caution; interpretation of results from well controlled studies may only hold true for the experiment from which they were attained, and may be of little use when attempting to determine nutritional requirements.
 
 
 

C. G. Rousseaux, A. Olkowski, A. Chauvet, R. Gooneratne, and D. A. Christensen, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

SULPHATE-RELATED NEUROLOGICAL DISEASE IN SHEEP
 

Fifty-six female cross-bred 2 month old sheep were housed in individual cages, and fed a basic ration of barley (48%) soybean meal (20%) and alfalfa (32%) mixture prepared to meet NRC requirements. The diets contained sulphur (.19% low level/ .63% high level) copper (6.7 mg/Kg low level/28.8 mg/Kg high level), and thiamine (13.7 mg/Kg low level/243 mg/Kg high level) as factors tested. All animals had free access to water and were offered 1 Kg/animal/day of diet for 14 weeks, at which time necropsy is undertaken. Gross lesions of polioencephalomalacia, some of which fluoresced, were noted in the animals treated with high levels of oral sulphur. Histological grading of pathological changes, with subsequent nonparametric statistical analysis, revealed treatment effects totally attributable to high sulphur intake. The cortical, extrapyramidal, limbic, motor, vestibular, visual, auditory and olfactory systems demonstrated more severe morphological changes in the low sulphur counterparts. Extrapyramidal lesions in sheep supplemented with thiamine were less severe in sheep receiving .63% sulphur in the diet. It was concluded that inorganic sulphur was associated with polioencephalomalacia and that dietary thiamine may decrease the severity of lesions in some affected areas of the central nervous system.
 
 
 

David W. Schnare, MSPH Ph.D. U.S. Environmental Protection Agency, Fairfax Station, Virginia

REDUCTION OF HUMAN POLYHALOGENATED BIPHENYL BURDENS
 

With increasing evidence of an etiological association between chemical body burdens and compromise in human health and function, there has been an increase in interest in means to reduce or remove chemical burdens stored in the human body. This paper describes the efficacy of one such treatment regimen, indicating those areas of research which, if pursued, would be helpful in extending understanding of chemical burden reduction, as well as in improving existing treatment methods.
 

The methods discussed rely on enhanced mobilization of lipid-stored contaminants, enhanced excretion (predominantly through a fecal/biliary route), and protection of liver function during mobilization. Approximately three weeks of treatment lead to large reductions in whole body burdens of polyhalogenated biphenyls of about 40 percent, well in excess of normal excretion/metabolism rates (half-lives in excess of a decade.)
 
 
 
 
 
 
 
 
 
 
 

Cyril W. Smith, Ph.D. Department of Electronic and Electrical Engineering University of Salford, M5 4WT, England

ELECTRICITY AND WATER: PART I
 

The remarkable properties of that common substance water, so essential to the existence and functioning of living systems are discussed from the fundamentals of all the sciences involved. The duality between chemical structure and coherent frequencies involves electrical oscillations in an essential way. The similarity between the actions of homeopathic potencies, allergens and coherent oscillations are considered in respect of the possibility of providing therapy or, producing "proving" symptoms in sensitive persons, through interactions involving structured water.
 

ELECTRICITY AND WATER: PART II

Data obtained during the testing of electrically hypersensitive patients will be presented. Examples of electric and magnetic field strengths and frequencies which produce various clinical effects will be presented. They will be discussed in respect of the theory of non-linear control systems and their environmental health implications.
 
 
 

Said Youdim, Ph.D. Dallas, Texas

IMMUNOLOGIC FACTORS IN AUTOIMMUNE DISEASE
 

Many theories and mechanism have been proposed for the generation of autoimmune response (see table). No single theory based on findings in humans or experimental models is universally acceptable or at least without certain amounts of controversy. This is not surprising given the complex nature of the prototype model of the autoimmune disease; systemic lupus erythematosis (SLE) which exhibits multisystem, multiorgan pathology with a considerable number of autoantibodies of high titer. This presentation discusses certain number of the mechanisms of autoimmune disease in the context of tolerance, self recognition, idiotypic, anti-idiotypic regulatory network and other immunologic factors. Other factors of critical importance in autoimmunity are genetic, virologic, and hormonal. These undoubtedly play essential roles each acting singularly or synchronously with the others to induce autoimmune disease.
 

THEORIES OF ORIGIN OF AUTOIMMUNITY
 

Release of sequestered antigens

Diminished suppressor T cell function

Enhanced helper T cell activity, T cell bypass

Thymic defects

Presence of abnormal clones, defects in tolerance induction

Polyclonal B cell activation

Refractoriness of B cells to suppressor messages

Defects in macrophages

Stem cell defects

Defects in the idiotype-anti-idiotype network

Abnormal genes: Immune response genes, immunoglobulin genes

Viral factors

Hormonal factors