What is Neurotoxicity?



Neurotoxicity

by

William J. Rea, M.D.*

Neurotoxicity is the damage to the brain and/or the peripheral nervous system from toxic chemicals. These chemicals include insecticides, solvents, lead, mercury, cadmium, car exhaust, formaldehyde, chlorine, phenol and thousands of others. Our environment has become polluted with large doses of these. It is difficult for the individual to avoid exposure. Symptoms for the brain toxicity are short term memory loss, loss of circulation, imbalance, and flu-like symptoms. For the peripheral the symptoms are numbness, tingling, loss of sensation and movement. The best test for the peripheral are the neurometer, and nerve conduction test. For the brain, the triple camera SPECT brain, the computerized balance, the pupillography, the heart rate variability, and a battery of psychiatric tests. Treatment consists of a massive avoidance of pollutants in air, food and water including specific toxic substances that the patient is commonly around, intravenous and/or nutrition, and injection therapy for the substance the patient has become sensitive to. These include food, biological inhalants and some chemicals, moderate temperature sauna, massage and exercise under environmentally controlled conditions. Often immune modulation is necessary using the patient's own autogenous lymphocytes.



*William J. Rea, M.D., Environmental Health Center - Dallas, Dallas, TX

Medical School Attended: Ohio State University College of Medicine, Residency: University of Texas SW Medical School; Parkland Memorial Hospital; Baylor Medical Center, Veteran's Hospital; Children's Medical Center, Board Certifications: American Board of Surgery; American Board of Thoracic Surgery; American Board of Environmental Medicine, Current Job Description: M.D./President - Environmental Health Center - Dallas









Neurotoxicity

by

Kaye Kilburn, M.D.*

Neurotoxicity encompasses injury from chemicals to the brain and to peripheral nerves, those outside the skull. As the brain is the body's master controller, primary effects on it affect many bodily functions. Historically common causes are lead, alcohol, mercury, organic solvents and insecticides. Newer ones are chlorine, rotten egg gas, ammonia, polyvinyl chloride (PVC) and polychlorinated biphenyls (PCBs). Perceived as complaints (symptoms) effects include altered feeling or moods (anxiety, depression, confusion, anger, extreme fatigue, short term memory loss, vertigo, imbalance, and flu-like symptoms with lack of concentration). Complaints and moods are subjective. Objective tests measure nervous system functions. Ranking of these confirms intuition with 4 prime tests: body balance, color discrimination and visual performance and a two choice visual reaction time. Tests of verbal memory, problem solving and mental coding and juggling make a second tier. Comparison of results in the subject before, versus after exposure are ideal but seldom possible. Next best is to calculate expected performances as predicted values adjusting for age, sex (yes, women are faster) and educational achievement (a practical measure of ability before exposure). Observed values are compared to these predicted ones and differences tested for significance (statistically).



*Kaye Kilburn, M. D.

University of Southern California Medical Center, Keck School of Medicine, Los Angeles, CA , Medical School Attended: University of Utah College of Medicine, Residency: University of Utah Hospitals, Board Certifications: California, Louisiana, North Carolina, Missouri, Wyoming, New York, Current Faculty Appointments: Professor of Medicine, University of Southern California Keck School of Medicine, Current Job Description: Director of Environmental Sciences Lab, Ralph Edgington Professor of Medicine, University of Southern California - Keck School of Medicine, Other Information: Editor-in-Chief, Archives of Environmental Health and President & Director, Neuro-Test, Inc.